Metal sensitivity

Alwaysdream · June 13, 2017, 9:33pm

Are there any genes related to metal sensitivity?

BB_Bryns · June 14, 2017, 3:09am

What kind of metal sensitivity are you wondering about?

I’ve been interested in this topic as well. I’m sensitive to nickel in both jewelry and foods (I get eczema when I eat foods high in nickel, like chocolate). Recently, I’ve wondered if my genetic variations have led to a build up of nickel in my body to the point that I became sensitive. I have some genetic variations that mean my liver is not very good at detoxing, so maybe I just have too much nickel in me and need to pull it out through detoxing or chelation, although I would have to go super slow and gentle to not overburden my inefficient liver!

Contact sensitivity to nickel is mostly from environmental factors, not genetic:

ncbi.nlm.nih.gov

Genetic factors in nickel allergy evaluated in a population-based female twin sample.

LE Bryld, C Hindsberger, KO Kyvik, T Agner and T Menné, The Journal of investigative dermatology, Dec 2004

Environmental exposures are important for development of allergic contact dermatitis, but genetic factors have been proposed to be of additional importance for contact sensitization. Recently genetic factors were shown to be of significance for hand eczema. In this study, a sample of twins recruited on the basis of hand eczema has been evaluated with respect to influence of genetic factors on development of nickel sensitization. A total of 1076 individual twins were patch tested and underwent clinical examination, and in the final genetic statistical analysis 630 females were available, of which 146 had a positive patch test to nickel. The aggregation of nickel allergy among twin pairs was measured by the casewise concordance and the twin odds ratio. The twin odds ratio were adjusted for effects of risk factors known to be associated with nickel allergy, namely, wet work, atopic dermatitis, and self-reported hand eczema. There was a small tendency for larger odds ratio among monozygotic twins than among dizygotic twins, which was not statistically significant. As a result of the statistical analysis, it is concluded that allergic nickel contact dermatitis is mainly caused by environmental and only to a lesser degree genetic factors. The selection of twins on the basis of hand eczema may theoretically influence the prevalence of nickel allergy and concordance estimates, which should be considered before extrapolating the data to a random population-based twin sample.

A low nickel diet and/or nickel chelation are possible therapies:

Alwaysdream · June 17, 2017, 3:50am

BB,

Thanks for your response! I have been having health issues and found out that I have metal clips in me from when I had my gallbladder removed. I am also unable to wear most jewelry because of sensitivity to metals. I have seen many Dr’s that tell me they have never heard of people being sensitive to sergerical clips. I appreciate the links you attached. I didn’t know if there are any genes related to metal sensitivity.

Dr_Mom · November 30, 2017, 12:50am

I’m allergic to aluminum because of RhoGam and allergy shots.

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Metal sensitivity

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