More likely to require pain medication with opioids after surgery, due to AG genotype for rs6269 compared to people with other genotypes. Anyone with a similar response to pain meds?
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Yes I do…I also developed a VERY high tolerance to opioids over a period of 6 years under doctors care. I had to find an alternative method to deal with chronic pain. I now request my surgeons,if at all possible, to use different medications. Never blocks and local anesthesia has worked for me…
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I hate opioids. Instead of helping my pain I feel grumpy and depressed when I take them. Many of my family members refuse all pain meds after surgery because it’s more trouble than it’s worth.
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Opiods make me feel awful and I can barely function on an effective pain killing dose. If I have to take them, I make sure it’s as brief as possible. 
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I make a lousy drug fiend. They don’t help pain, and I throw up a LOT!
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Look at the COMT chapter of the book Genetic Testing Defining Your Path to a Personalized Health Plan.
You will get a lot out of it. https://geneticdetoxification.com/book/