My sympathies re. your struggles w/ depression & anxiety. I can’t speak to any personal experience w/r/t depression or successful treatment thereof. However, as I lost a brother to a type of depression (Bipolar II), and as I’ve suspected that there may be a genetic predisposition in my family, I thought I’d offer the following:
First, though I don’t have the MTHFR variants, I do have other methylation-pathway defects: variant SNPs and at least one anomalous blood marker (serum homocysteine (Hcy)- a pro-inflammatory) I discovered these along with some clotting factor variants when I was researching poss. causes for DVT.
With a knowledgeable M.D.s approval, I am now taking daily folate, P5P & B12 supplements, similar to you… and the homocysteine level has dropped into reference range. I also take other supplements related to energy pathways… ALA, COQ10, and others. I think they’ve helped even beyond merely reducing the homocysteine; though other improvements are purely subjective.
As for depression: I might suggest that you also upload your raw DNA data to Promethease.com . I think there’s a fairly modest charge…perhaps it was $10 . For that you get to download not just a simple report, but a report-engine which you can then run anytime from your PC, and which has flexible search for various Genes, or medical conditions. You can filter just for “Depression”, for example, in the “Medical Conditions” drop-down list.
In my case, I found a number of SNPS in ABCB1 gene (also known as the MDR1 gene) that indicate “7x less likely to respond to certain antidepressants”. (Some of those are identified in the accompanying text, which comes from SNPedia.) That information might be valuable to you and your doctor, as it might point to optimal therapeutics.
I also found (when filtering for “Bipolar disorder”, quite a number of SNPs increasing odds of developing same. (Happy to say that thus far, I haven’t seemed to have developed it!) Once you id the variants, however, there is at least the possibility of looking at various research that is associated…including hints at treatment optimization.
I’m glad that you’re continuing to look to optimize your treatment. It’s no doubt a challenge, but I believe it’s quite doable; and you seem to be on the right track. Good luck.