Gene mutations and anti-depressants


My doctor wants to put me on anti-depressants due to terrible anxiety (adrenal fatigue/Hashimoto’s) and I saw once that certain mutations mean not to take them, particularly SSRIs. I cannot find that now anywhere. To my surprise he was concerned about that and he asked if I could find out what I can and cannot take. I am homozygous for COMT V158M, MTHFR 677T, MTRR A66G. Many others are heterozygous. I’ve never been able to get much out of all the massive data I got on this, way too confusing but I have to get this anxiety under control. It’s killing me. What can I take??


Eight genes with likely associations with treatment responses and summarized genetic variants most likely to influence treatment responses. Clinical recommendations already exist for CYP2D6 and CYP2C19 cytochrome P450 drug metabolism genes.

A good paper on related genes:

I recommend getting Dr. Ben Lynch’s book “Dirty Genes”. It covers the 7 most important genes for our health and how to correct them. Dr. Lynch has a Facebook page with videos on each of the genes. Do a Google search for 'Dr. Ben Lynch facebook" and click on the Video link in the sidebar.