It really is. I was on Medicaid at the time and they paid for it!
I’m no doctor but when it comes to my health and meds and illness, I geek out.
I ramble too much (symptom) so feel free to skip it all and go to the links below. They are important for the original poster.
I have had to become my own doctor and advocate. Because I was SO tangential, psych wanted to try bipolar meds. Heck no!!! Life finally defeated my spirit so I agreed to try other meds in addition to what I was on, against my own wisdom. Sure, I’ll try, but only after I researched all the meds in the results. I was SO powerless, it gave me a tiny sense of agency again. I’d point to green meds and doc would know the technical stuff, like post-synaptic or pre-synaptic mode, which are generally excitatory, etc.
It lays the ground for a conversation, basically. Psych only knew 1/18th of the whole picture.
I finally tried adding Buspar after some ‘huge research was published’ and it did nothing but prevent me from eating grapefruit. Immunologist knew all along that the cognitive symptoms were from a systemic immune source (hyper IgM that looks like multiple myeloma - off to the blood oncologist…).
When a test came back high and long-term for m.pneumonea (walking pneumonia) and a CT with calcified lymph nodes, I started taking an anti-biotic of sorts for mycoplasma. For leprosy, specifically! But this is long term - years to life.
MASSIVE side effects with the Buspar.
I just quit the Buspar on my own - lungs are more important. So while the Genesite test has 2-4 liver gene/enzyme tests, it doesn’t have all of them. It’s on us as patients to utilize our data and web resources “before it’s too late.” I learned the rest of the liver gene variants from livewello.com that Genesite missed, and the antibiotic was competing for the enzyme. Not fun.
Also, their “MTHFR” test is just that. So Psych gave me a couple months of high dose 5-methylfolate (more research in psych re: depression - so just throw massive amounts of one vitamin at it!) He was stumped when I came back 2 months later unchanged. Turns out I couldn’t even process 5-MTHF at that point. I had to add adenocobalamin and/or hydroxycobalamin for starters. Even methylcobalamin was stripped of whatever makes it work in the downstream process.
I presented this monster microbiology-genetic-nutrient diagram to both doctors and they were blown away. My immunologist is working with it because Serine is in a compromised cycle for me, and I have A1A-Def syndrome (aka rare lung disease) expressing yet I’m merely a carrier. Serine is the root of it the innate immune system and low C1, the key cytokenes behind A1A-def. So he’s writing research papers now (yay!).
I try to share it w/ everyone who mentions COMT or MTHFR because it opens up a whole new conversation with doctors. The good ones will get curious and start digging with you.
Another version that pulls in heavy metals and specific nutrients:
And you can upload your 23&me data to get a general idea of most of the genes identified:
Click the huge “Start Here” button to start uploading and see if/where your methylation cycle could use support.
This is new stuff, and one Ph.D.'s take on it. It turns out Shoemaker in the book Mold Warriors is wrong about how to collect C4a - based on experience. So the initial works that are always shot down by the Ivory Towers of Academia and Politics aren’t 100%, but they’re so much closer than “all in the mind.”
It’s the most thorough view I’ve found. So when the psychiatrist started saying my sleeping all the time and fatigue were depression, I whipped out the 2 diagrams above w/ my variants circled, which resulted in problems with SSRI, Dopamine (there are 2 MOA* markers, one flows down to Parkinson’s, the other ADHD etc), GABA (root of anxiety in a doctor’s view). Then I pointed over to the Kreb’s Cycle and said “I took Botany during my undergrad, this is energy at the cellular level and for me, it’s broken.”
Ding! I finally earned my credibility card with him.
Hope they help, if not already posted here.
(I know livewello doesn’t have a thorough methylation cascade variant report).