Does anyone else with severely low serotonin (based on symptoms and genetic test results including 5HT and SERT mutations) have strange reactions to ashwagandha?
I started taking ashwagandha (600 mg per day) to raise my non-existent testosterone (I’m a 30-something female) because, with MTHFR C677TT, my endocrinologist will not approve pellet therapy due to the risk of blood clots.
Ashwagandha makes me very relaxed. Unfortunately, it also causes depression and extreme hunger along with weight gain. I have been unable to find any source that explains the mechanism. I can’t even find a source that talks about side effects. Everyone whose comments I’ve read says ashwagandha is a miracle supplement, and they feel fabulous after taking it. I do take 5-HTP, which works wonderfully for the symptoms of low serotonin, but again, I can’t find anything that indicates they interact with each other.