I apologize for the long topic subject. I am really new to this in general with SNPs and reading these genetic reports with a proper eye. I have had psoriasis for the past 18 years since I was 13. And, now I was recently diagnosed with psoriatic arthritis involving my back and SI joints. They find bilaterial damage to my SI joints but it’s very mild.
They want to start me off with humira and NSAIDs but reading my SNPS apparently I have greater sensitivity to NSAIDS in general. I need help with using the information I have in regarding my SNPS to somehow figure out if medications like biologicals will work for me and take different supplements to control my psoriasis and psoriatic arthritis.
I’m just a bit overwhelmed trying to figure this all out and could use some guidance and help. By the way is there any geneticist doctor that treats people with autoimmune disorders and sulfur intolerance problems here in America or around the world? Any help with that as well would be greatly appreciated as well.
Genetically, my maternal haplogroup, U5a1b is prone to psoriasis and anklylosing spondylitis. Mom had psoriasis. All we know for sure is I have an inflammatory disease that responds to prednisone. (Well, I have other things wrong, notably, immune deficiency.) I can’t take NSAIDs and you probably can’t either. They make me bleed. I would not take a biologic because I’m sure I would get cancer so fast, it would make your head swim.
I take molybdenum for the sulfur problems, (CBS upregulation.)
I’ve taken NSAIDs on and off and haven’t had a bad reaction yet despite one of my SNPs saying I may have increased sensitivity. As for biologicals I do not know if I’m prone to it either or not. I thought there wasnt anyway to test this? And, I’ve gotten tested for hypothyroidism but the results came back normal.
Is there anyway I can show you all my entire SNPs I have one from Rhonda Patrick’s site and one here so how am I able to make you guys view my SNPs so you all have a better idea of what’s going on with my body risk wise to supplements or other medications and what may actually work with me as well.
Dr. Mom, what SNPs should I look for in order to determine if I have an immune deficiency? I tried looking up U5a1b but I didn’t get anything in the search results.
Non-secretors appear to have an increase in the prevalence of a variety of autoimmune diseases including ankylosing spondylitis, reactive arthritis, psoriatic arthropathy, Sjogren’s syndrome, multiple schlerosis, and Grave’s disease."
I have pictures of my immunoglobulin panel actually dr. mom here it is. Apparently everything is normal besides ESR which was 26 and CRP little on high side but within normal range at 8.63
HI Stufa, it is correct that there is no way to tell from your SNPs at the current time whether you will respond to biological agents. The only connection I know of is that having HLA B27 is associated with getting psoriatic arthritis. Your doctor should be able to go over the data for and against biologicals for psoriatic arthritis. One thing to consider asking about is the long term effects on the rest of your body (aside from the joints and skin) of the inflammation associated with psoriatic arthritis. There are data indicating that the risk of heart disease and stroke are elevated in all inflammatory arthritis conditions and that the biological agents can reduce this risk, in addition to helping with joint and skin inflammation. All medications have risks and benefits so I would suggest discussing the risk-benefit analysis with your doctor. The Arthritis Foundation has excellent information on this and related subjects. Here is a link to just one of the many sources of information on the Arthritis Foundation web site: https://www.arthritis.org/about-arthritis/types/psoriatic-arthritis/articles/psoriatic-arthritis-heart-disease.php
The maternal haplogroups also have associations with psoriasis, Crohns, AS etc. If you type your haplogroup into a search engine, you may find what you’re looking for.
I have psoriasis (from age 14) and osteoarthritis (from 22 years old) (suspected seronegative psoriatic arthritis too, but they don’t want to test as my treatment would remain the same)
I spent years on NSAIDS, then couldn’t take them as they damaged my stomach lining, I’m waiting for tests to confirm an ulcer now. If they want you on NSAIDS, ask for stomach protectors like pantoprazole, to protect you from future damage.
I’ve been on Stelara (ustekinumab) immunosuppressant for my psoriasis since 2015, I was 100% clear, now still 95% clear. I’ve had no side effects. Considering how bad my skin and mental health was, it’s been a miracle drug.
